Sulfamethoxazole

 Cat.No.£ºIC-013389

Product Information

Biological Activity

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 ¦ÌM. Sulfamethoxazole is most often used as a part of synergistic combination with trimethoprim in a 5:1 ratio in co-trimoxazole. Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

50mg

$105.00

€87.50

In stock

500mg

$195.00

€162.50

In stock

1g

$320.00

€266.67

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

253.28

Formula

C₁₀H₁₁N₃O₃S

CAS Number

723-46-6

Purity

>98%

Solubility

50 mg/mL in DMSO

Storage

at -20¡ãC

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