SB 202190

Cat.No.£ºIC-012062

Product Information

Biological Activity

SB 202190 is a potent p38 MAPK inhibitor. SB 202190 binds within the ATP pocket of the active kinase (Kd =
38 nM, as measured in recombinant human p38), and selectively inhibits the p38¦Á and ¦Â isoforms (IC50 = 50
and 100 nM at SAPK2a/p38 and SAPK2b/p38¦Â 2 respectively). SB 202190 by itself was sufficient to induce
cell  death,  with  typical  apoptotic  features  such  as   nucleus  condensation  and  intranucleosomal  DNA
fragmentation.  SB  202190  stimulated  the  activity  of  CPP32-like  caspases,  and  its  apoptotic  effect  was
completely blocked by the expression of bcl-2. When tested at 10 ¦ÌM, SB 202190 has negligible effects on a
range of other kinases, including other MAP kinases (ERKs, JNKs). Recently, SB 202190 has been used to
elucidate  the  roles  of  p38  MAP  kinases  in  inflammatory  cytokine  expression,  nicotine-induced  receptor
expression, and HIV-mediated depressive disorder.

Conversion of different model animals based on BSA (Value based on data from FDA Draft
Guidelines)

Species

Mouse

Rat

Rabbit

Guinea

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for
a rat,  multiply 22.4  mg/kg by the Km factor for a mouse and then divide by the Km factor for a  rat. This
calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

50mg

$53.40

€ 64.08

£¤534.00

£¤10,626.60

250mg

$213.60

€ 256.32

£¤2,136.00

£¤42,506.40

1g

$747.60

€ 897.12

£¤7,476.00

£¤148,772.40

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

331.34

Formula

C20H14FN3O

CAS Number

152121-30-7

Purity

99.91%

Solubility

DMSO 50 mg/mL

Storage

at -20¡ãC