Norbinaltorphimine,105618-26-6

Cat.No.:IC-0324876

Product Information

Biological Activity

Norbinaltorphimine is a selective antagonist of kappa-opioid receptor. nor-Binaltorphimine has a long-lasting effect in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price(€)

Price(£¤/CNY)

1mg

$85.00

€102.00

£¤850.00

5mg

$275.00

€330.00

£¤2,750.00

10mg

$440.00

€528.00

£¤4,400.00

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

661.79

Formula

C40H43N3O6

CAS Number

105618-26-6

Purity

>98.00%

Solubility

DMSO: ¡Ý 100 mg/mL (151.11 mM)

Storage

¡ª20¡ãC, protect from light

Reference

[1]. Spanagel R, et al. Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes. Eur J Pharmacol. 1994 Oct 24;264(2):157-62.

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