Procyanidin B2,29106-49-8

Cat.No.:IC-03310174

Product Information

Biological Activity

Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducingautophagy process,and exerts a variety of potent protective pharmacological effects on diabetic complications.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

578.52

Formula

C30H26O12

CAS No.

29106-49-8

Purity

 >98%

Solubility

DMSO¡Ü50 mg/mL(86.43 mM);
H2O¡Ü65 mg/mL(112.36 mM).

Storage

2-8¡æ

Reference

[1]Zhang JQ, Gao BW, et al. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. Oxid Med Cell Longev. 2016;2016:6147345.
[2]Zhou Y, Li BY, et al. Restoration of Mimecan Expression by Grape Seed Procyanidin B2 Through Regulation of Nuclear Factor-kappaB in Mice With Diabetic Nephropathy. Iran J Kidney Dis. 2016 Sep;10(5):325-331.

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-03310174

1mg

$58.00

€ 69.60

£¤580.00

£¤11,542.00

IC-03310174

5mg

$182.20

€ 218.64

£¤1,822.00

£¤36,257.80

IC-03310174

10mg

$310.50

€ 372.60

£¤3,105.00

£¤61,789.50

IC-03310174

25mg

$607.50

€ 729.00

£¤6,075.00

£¤120,892.50

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