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5-Azacytidine,IC-0121697
Click£º1214     Release date£º2020-6-24    Author£ºAdministrator    Source£ºOriginal

5-Azacytidine,IC-0121697


5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4].

[1]. Christman JK. 5-Azacytidine and 5-aza-2''''-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.
[2]. Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2''''-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8.
[3]. Li LH,et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9.
[4]. Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-0121697

100mg

$52.50

€ 63.00

£¤525.00

£¤10,447.50

IC-0121697

500mg

$210.00

€ 252.00

£¤2,100.00

£¤41,790.00

IC-0121697

5g

$630.00

€ 756.00

£¤6,300.00

£¤125,370.00


On an article£ºNRF2 Inhibitor,IC-0199622
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