Reagent
5-Azacytidine,IC-0121697
Click£º1214 Release date£º2020-6-24 Author£ºAdministrator Source£ºOriginal
5-Azacytidine,IC-0121697
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4].
[1]. Christman JK. 5-Azacytidine and 5-aza-2''''-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.
[2]. Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2''''-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8.
[3]. Li LH,et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9.
[4]. Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.
[1]. Christman JK. 5-Azacytidine and 5-aza-2''''-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.
[2]. Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2''''-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8.
[3]. Li LH,et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9.
[4]. Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.
Order Information |
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Cat./REF. |
Size |
Price($£© |
Price(€) |
Price(£¤/CNY£© |
Price(£¤/JYP£© |
IC-0121697 |
100mg |
$52.50 |
€ 63.00 |
£¤525.00 |
£¤10,447.50 |
IC-0121697 |
500mg |
$210.00 |
€ 252.00 |
£¤2,100.00 |
£¤41,790.00 |
IC-0121697 |
5g |
$630.00 |
€ 756.00 |
£¤6,300.00 |
£¤125,370.00 |
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