Elesclomol£¬IC-0212400
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) ¦Á2/¦Á3 helices and ¦Â5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].
Apoptosis Analysis[3]
| Cell Line: | HSB2 cells |
| Concentration: | 200 nM |
| Incubation Time: | 18 hours |
| Result: | Increased the number of early and late apoptotic cells. |
| Animal Model: | Cardiac Ctr1 knockout mice[4] |
| Dosage: | 10 mg/kg |
| Administration: | Subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54 |
| Result: | Ameliorated severe cardiac pathology with a partial reduction in hypertrophy. |
[2]. Peter Tsvetkov, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul;15(7):681-689.
Order Information
Cat./REF.
Size
Price($£©
Price(€)
Price(£¤/CNY£©
Price(£¤/JYP£©
IC-0212400
1mg
$65.00
€ 78.00
£¤650.00
£¤12,935.00
IC-0212400
10mg
$105.00
€ 126.00
£¤1,050.00
£¤20,895.00
IC-0212400
100mg
$187.50
€ 225.00
£¤1,875.00
£¤37,312.50
IC-0212400
500mg
$562.50
€ 675.00
£¤5,156.25
£¤111,937.50
