Streptozocin,

18883-66-4

Cat.No.:

IC-0225481

Product Information

Biological Activity

Streptozocin is a potent DNA-methylating antibiotic. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA.
Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). ALX appeares not to be toxic for the studied cell lines with estimated IC50 values of 2809, 3679 or over 4000 ¦Ìg/mL for HL60, K562 and C1498 cells, respectively. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. The IC50 values of Streptozocin are 11.7, 904 and 1024 ¦Ìg/mL for HL60, K562 and C1498 cells, respectively. Results also show that the murine leukemic cells are more resistant to Streptozocin and ALX cytotoxicity than human leukemic cells[2].
Streptozocin (STZ)-injected mice show tendency to have lower body weight than that observed in animals injected with ALX. Streptozocin -injected mice have significantly fewer splenocytes (22.2¡À3.2¡Á106; n=10) compared to mice injected with ALX (60.7¡À4.3¡Á106; n=15; p=0.01)[2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price(€)

Price(£¤CN)

Price(£¤JP)

100mg

$60.00

€72.00

£¤600.00

€11,940.00

500mg

$180.00

€216.00

£¤1,800.00

€35,820.00

1g

$275.00

€330.00

£¤2,750.00

€54,725.00

5g

$1,062.50

€1,275.00

£¤10,625.00

€211,437.50

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

265.22

Formula

 C8H15N3O7

CAS Number

18883-66-4

Purity

>98%

Solubility

H2O:113.3 mg/mL ;DMSO :83.33 mg/mL .Need ultrasonic and warming

Storage

 at -20¡ãC

Reference

[1]. Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90
[2]. Diab RA, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8
[3]. Acer S,et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016Jul-Aug;79(4):222-5

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