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Schizandrin B,61281-37-6 |
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Cat.No.:IC-C906731 |
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Product Information |
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Biological Activity |
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Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignin, is isolated from the fruit of Schisandra chinensis.In vitro: Schisandrin B has early been found to inhibit in vitro lipid peroxidation by NADPH/ ascorbate and cysteine/ferric systems in isolated rat liver microsomes. In addition, using electron spin resonance measurement, Sch B was shown to scavenge both in vitro hydroxyl and superoxide radicals. In contrast to that ¦Á-tocopherol produced prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B could only inhibit the peroxidation reaction [1].In vivo: Five days after a single injection of doxorubicin (Dox) administration (20 mg/kg IP), left ventricular (LV) performance in mice was depressed significantly and was improved by Sch B treatment. Sch B could prevent the Dox-induced lipid peroxidation increase, nitrotyrosine formation, as well as metalloproteinase activation in the heart. Additionally, the increased expression of phosphop38 MAPK and phospho-MAPK activated mitogen kinase 2 levels by Dox were found to be suppressed by Sch B treatment significantly. Moreover, Sch B also attenuated Dox-induced higher expression of LV proinflammatory cytokines, myocardial apoptosis, cardiomyocyte DNA damage, caspase-3 positive cells and phopho-p53 levels in mice [2]. |
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Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines) |
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Species |
Mouse |
Rat |
Rabbit |
Guinea pig |
Hamster |
Dog |
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Weight (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
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Body Surface Area (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
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Km factor |
3 |
6 |
12 |
8 |
5 |
20 |
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Animal A (mg/kg) = Animal B (mg/kg) multiplied by (Animal B Km / Animal A Km) |
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Order Information |
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Quantity |
Price($) |
Price(€) |
Availability |
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100mg |
$119.00 |
€142.80 |
In stock |
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500mg |
$380.00 |
€456.00 |
In stock |
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1g |
$599.00 |
€718.80 |
In stock |
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Free Delivery on orders over $350.00. |
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Chemical Information |
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Molecular Weight |
400.46 |
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Formula |
C23H28O6 |
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CAS Number |
61281-37-6 |
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Purity |
>99.00% |
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Solubility |
DMSO:100 mg/mL (249.71 mM£© |
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Storage |
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Reference |
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[1] Mak DH,Ip SP,Li PC,Poon MK,Ko KM. Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo. Mol Cell Biochem.1996 Dec 20;165(2):161-5. |
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[2] Thandavarayan RA,Giridharan VV,Arumugam S,Suzuki K,Ko KM,Krishnamurthy P,Watanabe K,Konishi T. Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PLoS One.2015 Mar 5;10(3):e0119214. |
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We Devoted Ourselves To The Development Of Biomedical Research Reagent. |
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